Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear. Here, we provide the first evidence that Toll-like receptor 4 (TLR4) is induced by hepatocyte-specific...

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Bibliografische gegevens
Hoofdauteurs: Machida, Keigo, Tsukamoto, Hidekazu, Mkrtchyan, Hasmik, Duan, Lewei, Dynnyk, Alla, Liu, Helene Minyi, Asahina, Kinji, Govindarajan, Sugantha, Ray, Ratna, Ou, Jing-hsiung James, Seki, Ekihiro, Deshaies, Raymond, Miyake, Kensuke, Lai, Michael M.-C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635765/
https://ncbi.nlm.nih.gov/pubmed/19171902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807390106
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