Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear. Here, we provide the first evidence that Toll-like receptor 4 (TLR4) is induced by hepatocyte-specific...

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Detalles Bibliográficos
Main Authors: Machida, Keigo, Tsukamoto, Hidekazu, Mkrtchyan, Hasmik, Duan, Lewei, Dynnyk, Alla, Liu, Helene Minyi, Asahina, Kinji, Govindarajan, Sugantha, Ray, Ratna, Ou, Jing-hsiung James, Seki, Ekihiro, Deshaies, Raymond, Miyake, Kensuke, Lai, Michael M.-C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635765/
https://ncbi.nlm.nih.gov/pubmed/19171902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807390106
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