Placenta growth factor induces 5-lipoxygenase–activating protein to increase leukotriene formation in sickle cell disease

Individuals with sickle cell disease (SCD) have increased inflammation, a high incidence of airway hyperreactivity (AH), and increased circulating leukotrienes (LT). We show that expression of 5-lipoxygenase and 5-lipoxygenase activating protein (FLAP), key catalytic molecules in the LT pathway, wer...

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Bibliographic Details
Main Authors: Patel, Nitin, Gonsalves, Caryn S., Yang, Minyang, Malik, Punam, Kalra, Vijay K.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635078/
https://ncbi.nlm.nih.gov/pubmed/18945963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-169821
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