Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

Phenylene ethynylenes comprise a prototypical class of synthetic antimicrobial compounds that mimic antimicrobial peptides produced by eukaryotes and have broad-spectrum antimicrobial activity. We show unambiguously that bacterial membrane permeation by these antimicrobials depends on the presence o...

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Detalhes bibliográficos
Main Authors: Yang, Lihua, Gordon, Vernita D., Trinkle, Dallas R., Schmidt, Nathan W., Davis, Matthew A., DeVries, Clarabelle, Som, Abhigyan, Cronan, John E., Tew, Gregory N., Wong, Gerard C. L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634941/
https://ncbi.nlm.nih.gov/pubmed/19106303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806456105
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