The structural basis of integrin-linked kinase–PINCH interactions

The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-Å crystal structure of the ILK ankyri...

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Hauptverfasser: Chiswell, Brian P., Zhang, Rong, Murphy, James W., Boggon, Titus J., Calderwood, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634877/
https://ncbi.nlm.nih.gov/pubmed/19074270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811415106
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