Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

Epidermal growth factor receptor (EGFR) is overexpressed in ovarian carcinomas, with direct or indirect activation of EGFR able to trigger tumour growth. We demonstrate significant activation of both signal transducer and activator of transcription (STAT)3 and its upstream activator Janus kinase (JA...

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Detalhes bibliográficos
Main Authors: Colomiere, M, Ward, A C, Riley, C, Trenerry, M K, Cameron-Smith, D, Findlay, J, Ackland, L, Ahmed, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634691/
https://ncbi.nlm.nih.gov/pubmed/19088723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604794
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