Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

Epidermal growth factor receptor (EGFR) is overexpressed in ovarian carcinomas, with direct or indirect activation of EGFR able to trigger tumour growth. We demonstrate significant activation of both signal transducer and activator of transcription (STAT)3 and its upstream activator Janus kinase (JA...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Colomiere, M, Ward, A C, Riley, C, Trenerry, M K, Cameron-Smith, D, Findlay, J, Ackland, L, Ahmed, N
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634691/
https://ncbi.nlm.nih.gov/pubmed/19088723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604794
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