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Inhibition of Rho Kinase (ROCK) Leads to Increased Cerebral Blood Flow and Stroke Protection

BACKGROUND AND PURPOSE: Endothelium-derived nitric oxide (NO) plays a pivotal role in vascular protection. The Rho kinase (ROCK) inhibitor, hydroxyfasudil, prevents the downregulation of endothelial NO synthase (eNOS) under hypoxic conditions. However, it is unknown whether inhibition of ROCK can at...

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Bibliografski detalji
Glavni autori: Rikitake, Yoshiyuki, Kim, Hyung-Hwan, Huang, Zhihong, Seto, Minoru, Yano, Kazuo, Asano, Toshio, Moskowitz, Michael A., Liao, James K.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633591/
https://ncbi.nlm.nih.gov/pubmed/16141422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.STR.0000181077.84981.11
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