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Production of recombinant AAV vectors encoding insulin-like growth factor I is enhanced by interaction among AAV rep regulatory sequences

BACKGROUND: Adeno-associated virus (AAV) vectors are promising tools for gene therapy. Currently, their potential is limited by difficulties in producing high vector yields with which to generate transgene protein product. AAV vector production depends in part upon the replication (Rep) proteins req...

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Detalhes bibliográficos
Main Authors: Shi, Shuiliang, Mercer, Scott A, Dilley, Robert, Trippel, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633264/
https://ncbi.nlm.nih.gov/pubmed/19128486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-3
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