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Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.

Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate deriva...

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Udgivet i:Infect Immun
Principais autores: Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Harada, K, Mori, Y, Kawasaki, A, Tanaka, A, Nagao, S, Tanaka, S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263318/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6735470/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.45.1.293-296.1984
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