XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

XLF-Cernunnos (XLF) is a component of the DNA ligase IV–XRCC4 (LX) complex, which functions during DNA non-homologous end joining (NHEJ). Here, we use biochemical and cellular approaches to probe the impact of XLF on LX activities. We show that XLF stimulates adenylation of LX complexes de-adenylate...

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Autores principales: Riballo, Enriqueta, Woodbine, Lisa, Stiff, Thomas, Walker, Sarah A., Goodarzi, Aaron A., Jeggo, Penny A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632933/
https://ncbi.nlm.nih.gov/pubmed/19056826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn957
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