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Chemical synthesis of oligodeoxyribonucleotides containing N3- and O(4)-carboxymethylthymidine and their formation in DNA
Humans are exposed to N-nitroso compounds from both endogenous and exogenous sources. Many N-nitroso compounds can be metabolically activated to give diazoacetate, which can result in the carboxymethylation of DNA. The remarkable similarity in p53 mutations found in human gastrointestinal tumors and...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2009
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632895/ https://ncbi.nlm.nih.gov/pubmed/19042973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn946 |
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