Enhanced Secretion of Biologically Active Murine Interleukin-12 by Lactococcus lactis

The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lacti...

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Bibliographic Details
Main Authors: Fernandez, Antonio, Horn, Nikki, Wegmann, Udo, Nicoletti, Claudio, Gasson, Michael J., Narbad, Arjan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Food Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632150/
https://ncbi.nlm.nih.gov/pubmed/19060166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01728-08
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