Crystal Structures of Cytochrome P450 105P1 from Streptomyces avermitilis: Conformational Flexibility and Histidine Ligation State

The polyene macrolide antibiotic filipin is widely used as a probe for cholesterol in biological membranes. The filipin biosynthetic pathway of Streptomyces avermitilis contains two position-specific hydroxylases, C26-specific CYP105P1 and C1′-specific CYP105D6. In this study, we describe the three...

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Hlavní autoři: Xu, Lian-Hua, Fushinobu, Shinya, Ikeda, Haruo, Wakagi, Takayoshi, Shoun, Hirofumi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Enzymes and Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631996/
https://ncbi.nlm.nih.gov/pubmed/19074393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01276-08
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