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Regio- and Stereospecificity of Filipin Hydroxylation Sites Revealed by Crystal Structures of Cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis

The polyene macrolide antibiotic filipin is widely used as a probe for cholesterol and a diagnostic tool for type C Niemann-Pick disease. Two position-specific P450 enzymes are involved in the post-polyketide modification of filipin during its biosynthesis, thereby providing molecular diversity to t...

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Detalhes bibliográficos
Main Authors: Xu, Lian-Hua, Fushinobu, Shinya, Takamatsu, Satoshi, Wakagi, Takayoshi, Ikeda, Haruo, Shoun, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878054/
https://ncbi.nlm.nih.gov/pubmed/20375018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092460
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