Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

Chondrocyte fate determination and maintenance requires Sox9, an intrinsic transcription factor, but is inhibited by Wnt/β-catenin signaling activated by extrinsic Wnt ligands. Here we explored the underlying molecular mechanism by which Sox9 antagonizes the Wnt/β-catenin signaling in chondrocyte di...

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Сохранить в:
Библиографические подробности
Главные авторы: Topol, Lilia, Chen, Wen, Song, Hai, Day, Timothy F., Yang, Yingzi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Molecular Basis of Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631972/
https://ncbi.nlm.nih.gov/pubmed/19047045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808048200
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