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Structural and Mechanistic Insights into Lunatic Fringe from a Kinetic Analysis of Enzyme Mutants
The Notch receptor is critical for proper development where it orchestrates numerous cell fate decisions. The Fringe family of β1,3-N-acetylglucosaminyltransferases are regulators of this pathway. Fringe enzymes add N-acetylglucosamine to O-linked fucose on the epidermal growth factor repeats of Not...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631955/ https://ncbi.nlm.nih.gov/pubmed/19028689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805502200 |
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