Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse

BACKGROUND: Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors. RESULTS: We demonstrate a novel role for cholesterol during germ cell migration in mic...

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Main Authors: Ding, Jiaxi, Jiang, DeChen, Kurczy, Michael, Nalepka, Jennifer, Dudley, Brian, Merkel, Erin I, Porter, Forbes D, Ewing, Andrew G, Winograd, Nicholas, Burgess, James, Molyneaux, Kathleen
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631600/
https://ncbi.nlm.nih.gov/pubmed/19117526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-8-120
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