Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse

BACKGROUND: Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors. RESULTS: We demonstrate a novel role for cholesterol during germ cell migration in mic...

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Detalhes bibliográficos
Main Authors: Ding, Jiaxi, Jiang, DeChen, Kurczy, Michael, Nalepka, Jennifer, Dudley, Brian, Merkel, Erin I, Porter, Forbes D, Ewing, Andrew G, Winograd, Nicholas, Burgess, James, Molyneaux, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631600/
https://ncbi.nlm.nih.gov/pubmed/19117526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-8-120
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