Interferon-alpha and bortezomib overcome Bcl-2 and Mcl-1 over-expression in melanoma cells by stimulating the extrinsic pathway of apoptosis

We hypothesized that interferon-alpha (IFN-α) would enhance the apoptotic activity of bortezomib on melanoma cells. Combined treatment with bortezomib and IFN-α induced synergistic apoptosis in melanoma and other solid tumor cell lines. Apoptosis was associated with processing of procaspases-3, -7,...

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Autori principali: Lesinski, Gregory B., Raig, Ene T., Guenterberg, Kristan, Brown, Lloyd, Go, Michael R., Shah, Nisha N., Lewis, Adrian, Quimper, Megan, Hade, Erinn, Young, Gregory, Chaudhury, Abhik Ray, Ladner, Katherine J., Guttridge, Denis C., Bouchard, Page, Carson, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631434/
https://ncbi.nlm.nih.gov/pubmed/18922907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0426
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