A Phase I trial of Bortezomib and Interferon Alfa-2B in Metastatic Melanoma

The possibility that cytokine administration could enhance the anti-tumor effects of proteasome inhibition was explored. It was found that co-administration of bortezomib and interferon-α (IFN-α) induced synergistic apoptosis in human melanoma cell lines and prolonged survival in a murine model of m...

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Autori principali: Markowitz, Joseph, Luedke, Eric A., Grignol, Valerie P., Hade, Erinn M., Paul, Bonnie K., Mundy-Bosse, Bethany L., Brooks, Taylor R., Dao, Thao-Vi, Kondalasula, Sri Vidya, Lesinski, Gregory B., Olencki, Thomas, Kendra, Kari L., Carson, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174542/
https://ncbi.nlm.nih.gov/pubmed/24316557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000009
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