Irs2 Inactivation Suppresses Tumor Progression in Pten(+/−) Mice

Mutations in the phosphatase and tensin homologue (PTEN)/phosphatidylinositol-3 kinase-α (PI3K) signaling pathway are frequently found in human cancer. In addition, Pten(+/−) mice develop tumors in multiple organs because of the activation of the PI3K signaling cascade. Because activation of PI3K si...

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Detalhes bibliográficos
Main Authors: Szabolcs, Matthias, Keniry, Megan, Simpson, Laura, Reid, Latarsha J., Koujak, Susan, Schiff, Sarah C., Davidian, Giselle, Licata, Scott, Gruvberger-Saal, Sofia, Murty, Vundavalli V.V.S., Nandula, Subhadra, Efstratiadis, Argiris, Kushner, Jake A., White, Morris F., Parsons, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631340/
https://ncbi.nlm.nih.gov/pubmed/19095950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080086
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