COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice

A cardinal feature of peripheral inflammation is pain. The most common way of managing inflammatory pain is to use nonsteroidal antiinflammatory agents (NSAIDs) that reduce prostanoid production, for example, selective inhibitors of COX2. Prostaglandins produced after induction of COX2 in immune cel...

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Main Authors: Vardeh, Daniel, Wang, Dairong, Costigan, Michael, Lazarus, Michael, Saper, Clifford B., Woolf, Clifford J., FitzGerald, Garret A., Samad, Tarek A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631301/
https://ncbi.nlm.nih.gov/pubmed/19127021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37098
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