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Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-(α)thioester building blocks
Modification of a peptide-(α)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(α)thioester building blocks for the total chemical syn...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631171/ https://ncbi.nlm.nih.gov/pubmed/19177172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2007.01.030 |
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