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Molecular Mechanisms of Nrf2-Mediated Antioxidant Response
Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently identified as a Cullin 3-dependent substrate adaptor protein. A two-sites binding “hinge & latch” model vividly dep...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631094/ https://ncbi.nlm.nih.gov/pubmed/18618599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20465 |
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