Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

BACKGROUND: NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II drug metabolizing/detoxifying genes through binding to the antioxidant response elements (ARE). NRF2-ARE signaling plays a central role in protecting cells from a wide spectrum of reactive toxic species inclu...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Ying, Li, Wenge, Kong, Ah-Ng Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519783/
https://ncbi.nlm.nih.gov/pubmed/23190551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-2-40
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