Single-chain Fv phage display propensity exhibits strong positive correlation with overall expression levels

BACKGROUND: Single chain Fvs (scFvs) are widely applied in research, diagnostics and therapeutic settings. Display and selection from combinatorial libraries is the main route to their discovery and many factors influence the success of this process. They exhibit low thermodynamic stability, resulti...

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Autori principali: Scott, Nathan, Reynolds, Catherine B, Wright, Michael J, Qazi, Omar, Fairweather, Neil, Deonarain, Mahendra P
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630973/
https://ncbi.nlm.nih.gov/pubmed/19113995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-97
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