Role for sphingosine kinase 1 in colon carcinogenesis

Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) and is a critical regulator of sphingolipid-mediated functions. Cell-based studies suggest a tumor-promoting function for the SphK1/S1P pathway. Also, our previous studies implicated the SphK1/S1P pathway i...

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Autori principali: Kawamori, Toshihiko, Kaneshiro, Tatsuya, Okumura, Masae, Maalouf, Samer, Uflacker, Andre, Bielawski, Jacek, Hannun, Yusuf A., Obeid, Lina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2009
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630788/
https://ncbi.nlm.nih.gov/pubmed/18824518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-117572
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