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Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations

This study investigated the effect of voriconazole, an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4, and itraconazole, an inhibitor of CYP3A4, on the pharmacokinetics and pharmacodynamics of meloxicam. Twelve healthy volunteers in a crossover study ingested 15 mg of meloxicam without pretrea...

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Detalhes bibliográficos
Main Authors: Hynninen, V. V., Olkkola, K. T., Bertilsson, L., Kurkinen, K. J., Korhonen, T., Neuvonen, P. J., Laine, K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630625/
https://ncbi.nlm.nih.gov/pubmed/19015346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00530-08
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