Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations

This study investigated the effect of voriconazole, an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4, and itraconazole, an inhibitor of CYP3A4, on the pharmacokinetics and pharmacodynamics of meloxicam. Twelve healthy volunteers in a crossover study ingested 15 mg of meloxicam without pretrea...

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Main Authors: Hynninen, V. V., Olkkola, K. T., Bertilsson, L., Kurkinen, K. J., Korhonen, T., Neuvonen, P. J., Laine, K.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630625/
https://ncbi.nlm.nih.gov/pubmed/19015346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00530-08
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