Reassessment of Recommended Imipenem Doses in Febrile Neutropenic Patients with Hematological Malignancies

Imipenem plasma concentrations were analyzed in 57 febrile neutropenic patients using the NONMEM program. The recommended 2-g/day regimen achieved coverage of the most common bacteria (MIC(90) = 1 mg/liter) during the whole dosing interval in only 53% of patients. This goal was achieved in 90% of pa...

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Bibliographic Details
Main Authors: Lamoth, F., Buclin, T., Csajka, C., Pascual, A., Calandra, T., Marchetti, O.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630622/
https://ncbi.nlm.nih.gov/pubmed/19047655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00891-08
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