High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function

High-dose cefepime therapy is recommended for febrile neutropenia. Safety issues have been raised in a recent meta-analysis reporting an increased risk of mortality during cefepime therapy. Cefepime-related neurological toxicity has been associated with overdosing due to severe renal dysfunction. Th...

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Bibliographic Details
Main Authors: Lamoth, F., Buclin, T., Pascual, A., Vora, S., Bolay, S., Decosterd, L. A., Calandra, T., Marchetti, O.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944571/
https://ncbi.nlm.nih.gov/pubmed/20625153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01595-08
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