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The DAF-2 Insulin-like Signaling Pathway Independently Regulates Aging and Immunity in C. elegans
The C. elegans DAF-2 insulin-like signaling pathway, which regulates lifespan and stress resistance, has also been implicated in resistance to bacterial pathogens. Loss-of-function daf-2 and age-1 mutants have increased lifespans (Kenyon et al. 1993; Larsen et al. 1995; Lithgow et al. 1995) and are...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630471/ https://ncbi.nlm.nih.gov/pubmed/18782349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00435.x |
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