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Cathepsin D is the main lysosomal enzyme involved in the degradation of α-synuclein and generation of its carboxy-terminally truncated species
α-Synuclein is likely to play a key role in the development of Parkinson's disease as well as other synucleinopathies. In animal models, overexpression of full-length or carboxy-terminally truncated α-synuclein has been shown to produce pathology. Although the proteosome and lysosome have been...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630205/ https://ncbi.nlm.nih.gov/pubmed/18702517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800699v |
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