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Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation

BACKGROUND: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent results indicate that not only the presence of a motif but also motif context (for example the orientation of a motif or its...

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Autori principali: Westholm, Jakub Orzechowski, Xu, Feifei, Ronne, Hans, Komorowski, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629780/
https://ncbi.nlm.nih.gov/pubmed/19014636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-484
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