Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy

BACKGROUND: A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the E-cadherin (CDH1) gene, which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-t...

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Main Authors: Lynch, Henry T., Kaurah, Pardeep, Wirtzfeld, Debrah, Rubinstein, Wendy S., Weissman, Scott, Lynch, Jane F., Grady, William, Wiyrick, Sara, Senz, Janine, Huntsman, David
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629639/
https://ncbi.nlm.nih.gov/pubmed/18442100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.23501
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