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Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy
BACKGROUND: A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the E-cadherin (CDH1) gene, which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-t...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629639/ https://ncbi.nlm.nih.gov/pubmed/18442100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.23501 |
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