Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

Normal cellular lifespan is contingent upon preserving outer mitochondrial membrane (OMM) integrity, as permeabilization promotes apoptosis. BCL-2 family proteins control mitochondrial outer membrane permeabilization (MOMP) by regulating the activation of the pro-apoptotic BCL-2 effector molecules,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chipuk, Jerry E., Fisher, John C., Dillon, Christopher P., Kriwacki, Richard W., Kuwana, Tomomi, Green, Douglas R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629294/
https://ncbi.nlm.nih.gov/pubmed/19074266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808036105
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg