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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
Normal cellular lifespan is contingent upon preserving outer mitochondrial membrane (OMM) integrity, as permeabilization promotes apoptosis. BCL-2 family proteins control mitochondrial outer membrane permeabilization (MOMP) by regulating the activation of the pro-apoptotic BCL-2 effector molecules,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629294/ https://ncbi.nlm.nih.gov/pubmed/19074266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808036105 |
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