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IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
Suppression of T-cell responses by host-derived regulatory factors is a key event leading to viral persistence. Antibody blockade of either IL-10 or programmed death-ligand 1 (PD-L1) during viral persistence enhances T-cell function and reduces viral titers. Because blockade of these immunoregulator...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629263/ https://ncbi.nlm.nih.gov/pubmed/19075244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811139106 |
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