REPRESSION OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE INVOLVES HDAC2 AND SNAIL IN COLORECTAL CANCER

Prostaglandin E(2) (PGE(2)) promotes cancer progression by modulating proliferation, apoptosis, angiogenesis and the immune response. Enzymatic degradation of PGE(2) involves the NAD(+)–dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGD...

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Autori principali: Backlund, Michael G., Mann, Jason R., Holla, Vijaykumar R., Shi, Qiong, Daikoku, Takikoku, Dey, Sudhansu K., DuBois, Raymond N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628771/
https://ncbi.nlm.nih.gov/pubmed/19010907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2893
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