Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

OBJECTIVE—To quantitate plasma ceramide subspecies concentrations in obese subjects with type 2 diabetes and relate these plasma levels to the severity of insulin resistance. Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in obe...

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Detalhes bibliográficos
Main Authors: Haus, Jacob M., Kashyap, Sangeeta R., Kasumov, Takhar, Zhang, Renliang, Kelly, Karen R., DeFronzo, Ralph A., Kirwan, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628606/
https://ncbi.nlm.nih.gov/pubmed/19008343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1228
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