Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

OBJECTIVE—The aim of this study was to find an effective treatment for the genetic form of diabetes that is present in some Huntington's disease patients and in Huntington's disease mouse models. Huntington's disease is a neurodegenerative disorder caused by a polyglutamine expansion...

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Main Authors: Martin, Bronwen, Golden, Erin, Carlson, Olga D., Pistell, Paul, Zhou, Jie, Kim, Wook, Frank, Brittany P., Thomas, Sam, Chadwick, Wayne A., Greig, Nigel H., Bates, Gillian P., Sathasivam, Kirupa, Bernier, Michel, Maudsley, Stuart, Mattson, Mark P., Egan, Josephine M.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2009
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628604/
https://ncbi.nlm.nih.gov/pubmed/18984744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0799
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