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Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and optimized methods for homologous DNA replacement using high-velocity particle bombardment to engineer 1,201 gene knockout mutants. We screene...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628477/ https://ncbi.nlm.nih.gov/pubmed/18854164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.046 |
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