Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and optimized methods for homologous DNA replacement using high-velocity particle bombardment to engineer 1,201 gene knockout mutants. We screene...

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Bibliografiske detaljer
Main Authors: Liu, Oliver W., Chun, Cheryl D., Chow, Eric D., Chen, Changbin, Madhani, Hiten D., Noble, Suzanne M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628477/
https://ncbi.nlm.nih.gov/pubmed/18854164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.046
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