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Erythrocyte-based Pig-a gene mutation assay: Demonstration of cross-species potential
Glycosylphosphatidylinositol (GPI) anchors attach specific proteins to the cell surface of hematopoietic cells. Of the genes required to form GPI anchors, only Pig-a is located on the X-chromosome. Prior work with rats suggests that the GPI anchor deficient phenotype is a reliable indicator of Pig-a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628466/ https://ncbi.nlm.nih.gov/pubmed/18790079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2008.08.011 |
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