Transcription inactivation through local refolding of the RNA polymerase structure

Structural studies of antibiotics not only provide a short cut to medicine allowing for rational structure-based drug design, but may also capture snapshots of dynamic intermediates that become ‘frozen’ after inhibitor binding1,2. Myxopyronin inhibits bacterial RNA polymerase (RNAP) by an unknown me...

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Detalhes bibliográficos
Main Authors: Belogurov, Georgiy A., Vassylyeva, Marina N., Sevostyanova, Anastasiya, Appleman, James R., Xiang, Alan X., Lira, Ricardo, Webber, Stephen E., Klyuyev, Sergiy, Nudler, Evgeny, Artsimovitch, Irina, Vassylyev, Dmitry G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628454/
https://ncbi.nlm.nih.gov/pubmed/18946472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07510
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