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The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex formed by 8 subunits (CSN1 through CSN8). Deneddylating cullin family proteins is considered the bona fide function of the CSN. It has been proposed that the CSN regulates the assembly and disassembly of the cullin-based ubiqu...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628451/ https://ncbi.nlm.nih.gov/pubmed/18706515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2008.07.008 |
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