HER2(YVMA) drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy

Mutations in the HER2 kinase domain have been identified in human clinical lung cancer specimens. Here we demonstrate that inducible expression of the most common HER2 mutant (HER2(YVMA)) in mouse lung epithelium causes invasive adenosquamous carcinomas restricted to proximal and distal bronchioles....

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Detalhes bibliográficos
Main Authors: Perera, Samanthi A., Li, Danan, Shimamura, Takeshi, Raso, Maria G., Ji, Hongbin, Chen, Liang, Borgman, Christa L., Zaghlul, Sara, Brandstetter, Kathleyn A., Kubo, Shigeto, Takahashi, Masaya, Chirieac, Lucian R., Padera, Robert F., Bronson, Roderick T., Shapiro, Geoffrey I., Greulich, Heidi, Meyerson, Matthew, Guertler, Ulrich, Chesa, Pilar Garin, Solca, Flavio, Wistuba, Ignacio I., Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626727/
https://ncbi.nlm.nih.gov/pubmed/19122144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808930106
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