HER2(YVMA) drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy

Mutations in the HER2 kinase domain have been identified in human clinical lung cancer specimens. Here we demonstrate that inducible expression of the most common HER2 mutant (HER2(YVMA)) in mouse lung epithelium causes invasive adenosquamous carcinomas restricted to proximal and distal bronchioles....

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Autors principals: Perera, Samanthi A., Li, Danan, Shimamura, Takeshi, Raso, Maria G., Ji, Hongbin, Chen, Liang, Borgman, Christa L., Zaghlul, Sara, Brandstetter, Kathleyn A., Kubo, Shigeto, Takahashi, Masaya, Chirieac, Lucian R., Padera, Robert F., Bronson, Roderick T., Shapiro, Geoffrey I., Greulich, Heidi, Meyerson, Matthew, Guertler, Ulrich, Chesa, Pilar Garin, Solca, Flavio, Wistuba, Ignacio I., Wong, Kwok-Kin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626727/
https://ncbi.nlm.nih.gov/pubmed/19122144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808930106
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