B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of α2–6-linked si...

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Bibliografiska uppgifter
Huvudupphovsmän: Cariappa, Annaiah, Takematsu, Hiromu, Liu, Haoyuan, Diaz, Sandra, Haider, Khaleda, Boboila, Cristian, Kalloo, Geetika, Connole, Michelle, Shi, Hai Ning, Varki, Nissi, Varki, Ajit, Pillai, Shiv
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2009
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626685/
https://ncbi.nlm.nih.gov/pubmed/19103880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081399
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