Polycomb Group Protein Bmi1 Is Required for Growth of RAF Driven Non-Small-Cell Lung Cancer

BACKGROUND: We have previously described a RAF oncogene driven transgenic mouse model for non small cell lung cancer (NSCLC). Here we examine whether tumor initiation and growth requires the stem cell self-renewal factor Bmi1. PRINCIPAL FINDINGS: In order to evaluate Bmi1 function in NSCLC two found...

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Detalhes bibliográficos
Main Authors: Becker, Matthias, Korn, Christian, Sienerth, Arnold R., Voswinckel, Robert, Luetkenhaus, Katharina, Ceteci, Fatih, Rapp, Ulf R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626631/
https://ncbi.nlm.nih.gov/pubmed/19156217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004230
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